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April 1, 1961


JAMA. 1961;175(13):1172. doi:10.1001/jama.1961.03040130056013

LEUBE in Germany and Sippy in the United States introduced the milk and alkali treatment of gastric-duodenal ulceration. And while occasional instances of alkalosis did occur, it was not until 1949 that Burnett1 and his associates described a "Syndrome Following Prolonged Intake of Milk and Alkali." The syndrome is characterized by hypercalcemia without hypercalciuria or hypophosphatemia, mild alkalosis, a normal serum alkaline phophatase, severe renal insufficiency with azotemia, and calcinosis manifested by the presence of band keratopathy. Improvement followed restriction of the intake of milk and absorbable alkali. Randall2 and his associates stress the variability of manifestations which may follow excessive intake of milk and report 4 cases to demonstrate the modifications of the syndrome.

One of their patients had ingested large amounts of milk, sodium bicarbonate, and Sippy powders for 14 years. He showed on examination nontender swellings about the shoulders, injected eyes, and small white masses

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