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To the Editor:—
I read with great interest the article by Dr. Whitelaw in The Journal, Feb. 4, p. 400. Apropos of Dr. Whitelaw's report, I think that some comments concerning the use of chlordiazepoxide in my practice are in order.In the autumn of 1959 Hoffmann-LaRoche released to me a supply of chlordiazepoxide capsules containing 10 and 25 mg. of the preparation. I have administered this preparation to approximately 300 patients (clinical records were kept on the first 75), and I found that menstrual irregularities associated with its use were insignificant and rare. In fact, it was only occasionally that a patient inquired of the possible effect of the medicine on the menstrual cycle. When it was explained that only occasionally did it interfere, the patient accepted this calmly and casually and no further mention was made of it. Therefore, I did not find it necessary to pursue the
Kamman GR. Chlordiazepoxide. JAMA. 1961;175(13):1184. doi:10.1001/jama.1961.03040130068024