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May 6, 1961


JAMA. 1961;176(5):440. doi:10.1001/jama.1961.03040180042011

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ANOTHER agent for the relief of the pruritus of jaundice, a bile-acid-sequestering resin, has now been investigated, and it appears that the resin is helpful not only for the pruritus but also in providing some interesting observations on the longdebated question of the relationship of bile acids to pruritic jaundice.

Of the various symptoms associated with jaundice, pruritus is often the most distressing, especially when prolonged; threatened or actual suicide has been attributed to the relentless torment of this condition. Numerous medications have been tried with but temporary or sporadic benefit: ergotamine, emetine, calomel, intravenous procaine, antihistamines, sweat baths, colloid baths, and lotions, to mention only a few. Currently, the most effective agents are methyltestosterone and norethandrolone. The manner in which these androgens effect relief of pruritus is not understood, but this is of little concern to the patient if his itching disappears, and the increased icterus which often accompanies

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