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May 6, 1961

Carcinoma of the Parathyroid with Hyperparathyroidism and Metastases

Author Affiliations

Hoboken, N.J.

From the departments of pathology, medicine, and surgery, St. Mary Hospital. Dr. Ehrlich is Director of Laboratories, St. Mary Hospital, and Assistant Professor of Pathology, Seton Hall College of Medicine and Dentistry.

JAMA. 1961;176(5):453-455. doi:10.1001/jama.1961.63040180013016d

FUNCTIONAL CARCINOMA of the parathyroid gland is a rare disease. Based on criteria of endocrine hyperactivity and metastases or recurrent tumor, less than 30 cases have been reported in the literature.1,2,3,5,6 Albright and Reifenstein5 accepted only 3 cases up to 1948. The following case report of carcinoma of the parathyroid is of interest because the patient's severe clinical symptoms of hyperparathyroidism recurring 2 years after the removal of the primary tumor were associated with widespread cervical metastases.

Report of a Case  A 53-year-old man was admitted to St. Mary Hospital, Hoboken, N. J., for the first time in September, 1958, complaining of pain in the ankles, nausea, vomiting, and weakness of 2 months' duration. Pain in the tibial region was increased and was so severe that he had difficulty in walking.Physical examination on admission revealed a chronically ill, short, stocky white male with a pulse rate

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