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May 13, 1961

THE CINCINNATI EXPERIMENT WITH ORAL ATTENUATED POLIOVIRUS VACCINE

JAMA. 1961;176(6):520-521. doi:10.1001/jama.1961.03040190042012
Abstract

The 1959 trials on large numbers of susceptible persons of various ages, carried out in several countries outside of the United States by Sabin and co-workers, established the safety and effectiveness of an oral live poliovirus vaccine. These experiments results of which appear in this issue of The Journal, p. 524, gave additional support to the possibility that poliovirus disease could be completely eliminated. Chumakov,1 of the Institute for Poliomyelitis Research in Moscow, states that 76 million persons received oral poliovaccine in the U.S.S.R. in 1960, and more than 100 million of all countries are included.

The Cincinnati Board of Health experiment, under the aegis of Sabin, has been published in the current issue of the American Journal of Diseases of Children. Attenuated poliovirus was given within a short period of time to 181,784 persons in Cincinnati and adjacent Hamilton County. There were 67,634 preschool children, 111,127 school children,

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