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May 13, 1961

Congenital Septal Dysplasia of the Heart Causing Sudden Death

Author Affiliations

Dayton, Ohio

From the departments of pathology and internal medicine, Miami Valley Hospital.; Resident in Pathology and Chief Resident (Dr. Funkhouser); and Associate Attending Physician, departments of Internal Medicine and Research (Dr. Weinberg).

JAMA. 1961;176(6):528-529. doi:10.1001/jama.1961.63040190010016b

AORTIC STENOSIS has long been recognized as a cause of sudden death. The inevitably bad prognosis in obstructive disease of the left ventricle has led to intensive diagnostic study and courageous surgical assault, with impressive results in recent years. As a consequence of new interest stimulated by successful surgical approaches, variant forms of obstruction to the left ventricular outflow tract are being reported. Brock1 has noted obstruction to the left ventricle in cases of hypertrophy, which he attributes to hypertensive disease. Bercu and associates2 have described pseudoaortic stenosis in the presence of symmetrical hypertrophy without hypertension. An intriguing concept was offered by Teare3 in 1958, in which he suggested that hypertrophy of the ventricular septum might compromise the outflow tract of the left ventricle and cause a clinical syndrome simulating that of aortic stenosis and resulting in sudden death. A recent clinical experience corroborates the findings

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