A specific immunochemical technique was used for the quantitative measurement of serum beta-lipoproteins in 124 premenopausal and 248 postmenopausal women. The mean premenopausal and postmenopausal levels were 1.9 ± 0.6 and 2.5 ± 1.0 immunocrit units, respectively. There was significant correlation of serum beta-lipoprotein levels with age for the group as a whole, but this appeared to have been the result of a relatively sharp rise in the mean level at the time of the menopause. Postmenopausal patients may benefit from estrogen-replacement therapy, not only for the relief of vasomotor symptoms but also because of the possible prophylactic effects with respect to eventual development of atherosclerotic disease.
Heiskell CL, Yachi A, Aldrich HJ, Carpenter CM. Serum Beta-Lipoproteins in the Preand Postmenopausal Female. JAMA. 1961;176(7):585-587. doi:10.1001/jama.1961.03040200021006