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June 3, 1961

TULAREMIA VACCINE

JAMA. 1961;176(9):806. doi:10.1001/jama.1961.03040220054014

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Abstract

A report on the efficacy of a vaccine for tularemia by Saslaw and associates of the Ohio State University Health Center has been published in the current issue of Archives of Internal Medicine. Thirty-one male volunteers, inmates of the Ohio State Penitentiary, were the experimental subjects. These included a vaccinated group of 14, a nonvaccinated group of 4, and a control group of 8. A rigid physical examination was performed to rule out concurrent diseases. Extensive laboratory tests were made before and during the several weeks observation. Fourteen were vaccinated on 3 successive days by subcutaneous injection of Foshay's killed tularemia vaccine. After 3 days of hospitalization to establish base line temperature data they were challenged by the SCHU S 4 strain of P. tularemia. Of the 14 so vaccinated, 12 showed local lesions at the site of injection while 4 of these had more serious constitutional signs, viz., headache,

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