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June 10, 1961

Quantitative Studies on the Clearing Effect of Heparin

Author Affiliations

New York City

From the Gilman Laboratory, Department of Medicine and Biochemistry, New York Medical College, Flower and Fifth Avenue Hospitals.

JAMA. 1961;176(10):871-873. doi:10.1001/jama.1961.63040230007013

THE PLASMA turbidity in alimentary lipemia is probably due to the presence of certain amounts and types of visible lipid particles. The role heparin plays in the serum-transport phase of fat metabolism has been intensively studied. The fact that intravenous administration of heparin brings about clearing of alimentary lipemia was demonstrated almost two decades ago by Hahn1 and confirmed by numerous investigators.2 Weld3 and Anderson and Fawcett4 carried out these studies with in vitro systems. Additional experiments have shown that injection of heparin also brings about some alterations in the circulating serum lipoproteins.5 Reports on the efficacy of heparin in the treatment of angina pectoris conflict.

Although the mechanism for the clearing action of heparin is not completely elucidated, most of the experimental findings lead to the conclusion that heparin effects the activation or appearance, in the blood, of a clearing factor which is the

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