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To the Editor:—
I believe it in order to comment on the reply by Dr. M. E. Davis (The Journal, March 4, p. 831) to the question submitted by the Brooklyn physician pertaining to generalized edema following administration of small doses of estrogens.I have observed a number of patients who have experienced varying degrees of edema following the administration of small to moderate doses of the standard estrogen preparations. It is true that most have had heart disease or were also receiving adrenocortical steroid therapy, but the role of estrogens in production of the edema was unequivocal. In my text, I cite one postmenopausal female who gained 10 pounds of weight within 3 days on 2 occasions after ingesting a total of 2 small estrogen tablets for symptomatic osteoporosis (Roberts, H. J.: Difficult Diagnosis: Guide to Interpretation of Obscure Illness, Philadelphia: W. B. Saunders Co., 1958, p. 325). Others
Roberts HJ. Menopausal Edema. JAMA. 1961;176(12):1053-1054. doi:10.1001/jama.1961.03040250079028