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July 22, 1961

Acute Autoimmune Hemolytic Anemia Complicating Infectious Mononucleosis

Author Affiliations

U.S. Navy

From the U.S. Naval Hospital, National Naval Medical Center, Bethesda, Md.

JAMA. 1961;177(3):210-212. doi:10.1001/jama.1961.73040290017013a

AS LATE as 1942, it was said that anemia of an appreciable degree, unexplained by some complicating factor such as hemorrhage or dietary deficiency, did not occur with infectious mononucleosis. In 1943 Dameshek1 reported hemolytic anemia in a patient with infectious mononucleosis who had received sulfadiazine therapy. The sulfadiazine was emphasized as the cause of hemolysis. Then in 1945, in a review of 300 individuals with infectious mononucleosis, Reed and Helwig2 reported 3 patients who had pancytopenia during the course of infectious mononucleosis. It was emphasized by the authors for the first time that the presence or absence of anemia was not significant in differentiating between infectious mononucleosis and leukemia, as previously supposed. Since then there have been about 23 reported cases of hemolytic anemia associated with infectious mononucleosis. The present case is one of infectious mononucleosis complicated by severe hemolysis and marked splenomegaly attributable to an

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