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To the Editor:—
The 1961 edition of the "Red Book" of the American Academy of Pediatrics distinguishes between the adult and the child dose for the first time in its recommendations for the prevention of infectious hepatitis. The dose amounts to 2 1/2 times more per pound of body weight for adults than for children.These recommendations resemble those of Krugman et al. (JAMA174:823-830 [Oct. 15] 1960) and do not take into account 10 years of satisfactory experience and published reports by many workers using the dose of 0.01 cc. per pound of body weight first advocated by Stokes et al. 10 years ago. In the Krugman trials this dose did not show the satisfactory results of previous published reports. The lot of globulin used by him at this dosage was not tested at any other dosage level. When he employed a higher dosage in his next trial,
Gellis SS, McComb JA. Help Conserve Gamma Globulin. JAMA. 1961;177(7):529–530. doi:10.1001/jama.1961.03040330065017