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August 26, 1961


JAMA. 1961;177(8):568-569. doi:10.1001/jama.1961.03040340032008

In recent years the use of platelet infusions to stop hemorrhages associated with thrombopenia has been increasing. According to Baldini,1 to be effective the infused platelets must be capable of remaining in the blood stream of the recipient for some time. A constant search is, therefore, being made to find a means of maintaining the viability of stored platelets. It is also important to evaluate the magnitude of the bleeding tendency and the effectiveness of systemic hemostatic measures in the thrombopenic patient. Such evaluations are difficult because the bleeding tendency may be severe and the platelet count only moderately depressed in some patients, while in others a moderate bleeding tendency may be associated with a low platelet count.

Racugglia and Bethell2 attempted to correlate thromboelastography, clot retraction, serum prothrombin time, platelet count, capillary fragility, and bleeding time with the clinical findings in thrombopenic patients during a hemorrhagic episode,

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