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August 26, 1961

Calcification in a Benign, Nonfunctioning Tumor of the Adrenal

Author Affiliations

New York City

From the departments of medicine and urology, College of Physicians, Columbia University, the Presbyterian Hospital, and the Squier Urological Clinic.; Fellow, United States Public Health Service (Dr. Drucker).

JAMA. 1961;177(8):577-579. doi:10.1001/jama.1961.73040340023012b

CALCIFICATION in a suprarenal mass is generally evidence of a malignant tumor of the adrenal. Few exceptions to this are recorded in the literature. McAfee and Balli1 cite 2 instances of cyst-like calcified adenomas, and the occasional occurrence of calcification in teratomas which may or may not show malignant change.2 McAfee and Balli also gathered several reports of pheochromocytoma with radiologically detectable calcium.1 Although this lesion is only rarely malignant, the consequences of its presence and the risks of surgical removal may be serious. Boice and Sears3 could find only 2 references to calcification occurring in a benign neoplasm of the adrenal—one purported to be a primary psammoma; the other, a pheochromocytoma. A review by Bachman4 calls attention to one other benign tumor, the histology of which was undetermined. Calcification of one or both adrenals in Addison's disease associated with tuberculosis or histoplasmosis is well

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