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To the Editor:—
In The Journal (176:747 [May 27] 1961) there is a question concerning new treatments for metastatic carcinoma of the pleura. I do not question the validity of the reply, but I believe it might have been desirable to mention the possible use of quinacrine ( Atabrine) hydrochloride in the control of neoplastic effusions. This has been reported by Gellhorn, et al. (Dis Chest39:165-176 [Feb.] 1961).While the number of cases reported has been relatively small, it does appear that quinacrine is effective in controlling neoplastic effusions and while its use is not unattended by side reactions, the drug has the advantage of lack of toxicity to the blood forming organs and does not involve the hazards of the radioactive isotopes.
Gibson A. Control of Neoplastic Effusions. JAMA. 1961;178(1):91. doi:10.1001/jama.1961.03040400093027