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October 21, 1961

IRRADIATION AND MARROW INFUSION IN ACUTE LEUKEMIA

JAMA. 1961;178(3):323-324. doi:10.1001/jama.1961.03040420063017
Abstract

Thomas and co-workers have reported recently1 on treatment of acute leukemia in 5 patients with total body irradiation followed by bone marrow infusion. The whole-body exposure consisted of 1,200 to 2,000 r. Marrow was obtained from volunteers, fetuses, or cadavers.

A 15-month-old female infant with acute leukemia was given an air dose of 1,460 r of wholebody irradiation from dual Co60 sources. She was then given intravenous infusions of marrow obtained from her mother. She developed an otitis media and later E. coli and died on the 21st day after irradiation. Autopsy showed no evidence of leukemia. There was considerable regeneration of the marrow. A 30-year-old man with acute leukemia received an air dose of 1,768 r of whole-body irradiation. This was followed first by infusions of fetal hematopoietic tissue and later by marrow obtained from an older brother. He developed an E. coli septicemia and died on

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