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October 28, 1961

Renal Radiation

Author Affiliations

Research Contract with U.S. Army Research and Development Command and National Heart Institute and Senior Research Fellow, National Heart Institute, St. Vincent Charity Hospital, Cleveland 15

JAMA. 1961;178(4):438-439. doi:10.1001/jama.1961.03040430074024

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Abstract

To the Editor:—  Drs. Mathes and Mayer (JAMA177:10-13 [July 8] 1961) suggest "cobalt radiation before... nephrectomy" as a "conservative" measure in essential hematuria.Renal radiation seems risky. In man, "acute radiation nephritis" (De Wardener, H. E.: Kidney, Boston: Little, Brown & Company, 1958), is not infrequent and has been reviewed elsewhere (Luxton, R. W., Quart J Med22:215-242 [April] 1953; Wilson, C., et al. Lancet1:9-16 [Jan. 4] 1958). Dog kidneys show early impairment of specific functions (Klapproth, H. J., et al., Lancet2:161-162 [Aug. 22] 1959) that are under study. Dr. F. K. Mostofi (personal communication, 1961) finds lesions 3 months after exposure of dog kidneys to 2,500 r. Rats develop delayed hypertension and excretory failure (Wilson, et al., supra): their kidneys rapidly lose phosphatase (Asscher, A. W. and S. G. Anson, Lancet1:1109-1110 [May 21] 1960) and rats develop hypertension before the

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