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To the Editor:—
Drs. Mathes and Mayer (JAMA177:10-13 [July 8] 1961) suggest "cobalt radiation before... nephrectomy" as a "conservative" measure in essential hematuria.Renal radiation seems risky. In man, "acute radiation nephritis" (De Wardener, H. E.: Kidney, Boston: Little, Brown & Company, 1958), is not infrequent and has been reviewed elsewhere (Luxton, R. W., Quart J Med22:215-242 [April] 1953; Wilson, C., et al. Lancet1:9-16 [Jan. 4] 1958). Dog kidneys show early impairment of specific functions (Klapproth, H. J., et al., Lancet2:161-162 [Aug. 22] 1959) that are under study. Dr. F. K. Mostofi (personal communication, 1961) finds lesions 3 months after exposure of dog kidneys to 2,500 r. Rats develop delayed hypertension and excretory failure (Wilson, et al., supra): their kidneys rapidly lose phosphatase (Asscher, A. W. and S. G. Anson, Lancet1:1109-1110 [May 21] 1960) and rats develop hypertension before the
Corcoran AC. Renal Radiation. JAMA. 1961;178(4):438–439. doi:10.1001/jama.1961.03040430074024