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November 4, 1961

Multiple Concordant Abnormalities in 79-Year-Old Identical Twins

Author Affiliations

Syracuse, N. Y.

Research Fellow in Hematology (Dr. Schiffer); Senior Student (Dr. Zucker); and Professor of Medicine (Dr. Lozner), Department of Medicine, Upstate Medical Center, State University of New York. Dr. Zucker is now an intern at Montefiore Hospital, Bronx, N. Y. After Sept. 1, 1961. Dr. Schiffer will be at the Medical Research Center, Brookhaven National Laboratory, Upton, L.I., N.Y.

JAMA. 1961;178(5):507-509. doi:10.1001/jama.1961.73040440021014b

THE CONCORDANT occurrence of disease and physical abnormalities in identical twins has been the subject of numerous reports. As far as we can determine, however, the 79-year-old identical twin sisters which we now present have a unique combination of illnesses. They both have pernicious anemia, peripheral facial nerve palsy, small bowel diverticula, and an asymptomatic sliding hiatus hernia. In addition, they both have had a benign intraductal papilloma of the breast and probably have had toxemia of pregnancy. Proof of their monozygosity is offered by means of skin cross-transplantation and identity of blood group factors.

Report of Cases 

Case 1.—  A 79-year-old woman states that in 1907 at the age of 25 she had convulsions before and during labor. In 1948 she suddenly developed a left peripheral facial nerve paralysis (Fig. 1). An upper gastrointestinal x-ray study in 1954 revealed the presence of several duodenal diverticula, and a sliding hiatus

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