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December 9, 1961

Coronary Blood Flow in Experimental Dumping Syndrome in the Dog

Author Affiliations

Los Angeles

From the Department of Surgery, College of Medical Evangelists School of Medicine, and the White Memorial Hospital.

JAMA. 1961;178(10):1012-1013. doi:10.1001/jama.1961.73040490008007b

THE "DUMPING SYNDROME" is a symptom complex described in patients following gastric operations in which the emptying mechanism of the stomach has been altered. It is composed of multiple physiological disturbances among which cardiovascular manifestations such as tachycardia, palpitation, sweating, and weakness are prominent. Electrocardiographic changes suggestive of myocardial ischemia have been noted in patients with this problem.1 It has been previously postulated that many of the symptoms which occur in the clinical dumping syndrome may result from reduced blood flow to vital body areas such as the heart and brain.2,3

The dumping syndrome may be experimentally simulated in the dog by the intrajejunal injection of hypertonic glucose solutions. Significant changes in blood flow have been demonstrated by this technique. Prominent among these changes are a marked increase in mesenteric blood flow and a concomitant, definite decrease in carotid and renal flow. A consistent, significant reduction in cardiac

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