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December 9, 1961


JAMA. 1961;178(10):1026-1027. doi:10.1001/jama.1961.03040490052012

As the study of the growth hormone derived from the anterior lobe of the hypophysis continues, much is being learned about its possible uses and its limitations. It was only natural that one of the uses to which it was put was to attempt to stimulate growth in dwarfs. Lipsett et al.1 administered human growth hormone (HGH) to 4 children who were primordial dwarfs, and to 4 acromegalic adults. In neither group did the hormone lead to nitrogen retention; it was, however, followed by an increase in the plasma level of unesterified fatty acid (UFA) and an increase in urinary calcium excretion in each group. The findings of an increase in serum UFA and urinary calcium excretion were evidences of HGH activity. It was concluded that the decreased growth in these patients was related to the inability of the HGH to cause nitrogen retention.

Escamilla et al.2 gave

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