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December 16, 1961

Use of Large, Germfree Animals in Medical Research

Author Affiliations

Little Rock, Ark.

JAMA. 1961;178(11):1084-1087. doi:10.1001/jama.1961.73040500001005

GERMFREE techniques can now be applied to " answer many previously insoluble problems. Important reasons for this are the improved technology and the cumulative experience in delivering, rearing, and utilizing germfree animals. Trexler1 introduced the flexible plastic isolator. We have constructed and maintained our own polyvinyl isolators since early 1960, shortly after the laboratory was formed. The cost of fabricating 55 of our units simultaneously operated to house germfree pigs and their control counterparts, germfree guinea pigs, supplies under test for sterility, and units for operative procedures is approximately equal to that of 3 stainless steel isolators. Regardless of cost, present rigid equipment is not suitable for the delivery and maintenance of the larger species of animals. Our project has been carried out with a full-time staff of 2 scientists and 4 technicians, which is comparable to that employed in other nongermfree projects of modest size. When germfree techniques

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