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January 6, 1962

Clinical Science

JAMA. 1962;179(1):63-65. doi:10.1001/jama.1962.03050010065011
Abstract

Heterologous Transplantation of Human Tumors  C. Schulte, K. Olson, M.D., and A. Stein, M.D., Albany, N.Y.ALTHOUGH heterologous transplantation of human tumors has been reported successful in the anterior chamber of the eye, the brain, and elsewhere, the yield has been small. However, the use of steroids and preinoculation irradiation have made it possible with greater success to transplant human tumors into many small laboratory animals such as rats, mice, and hamsters. These transplanted cells may not remain wholly human, to be sure, but they do offer a laboratory neoplastic source in adequate quantities, resembling the in situ nature of the human malignancy, for study. Therefore, it seemed justifiable to attempt to develop lines of transplantable human tumors. Heterologous transplantation of human tumors into the cheek pouch of hamsters treated with cortisone is now well documented.3-7We have transplanted a total of 126 tumors1 into the hamster's cheek

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