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This excellent volume records the proceedings of a conference organized by Morton I. Grossman in order to celebrate Prof R. A. Gregory's recent isolation of chemically pure gastrin from porcine stomachs, the determination of its structure and its synthesis, as well as his rather convincing evidence that the biologically active substance in the pancreatic adenoma of the Zollinger-Ellison syndrome is probably gastrin. The exciting story of gastrin is told in detail from Edkins (1905), the discoverer of gastrin (who paradoxically and ironically was measuring for the most part histamine activity), to Gregory's characterization of two gastrins reported in 1964.
Perhaps more important than the outstanding formal presentations was the free and spirited exchange of ideas following each paper, discussions skillfully led by the chairman. While some questions have been answered, there is still much to be learned, and the direction of future investigation is clearly indicated. The sites of gastrin
Lipp WF. Gastrin. JAMA. 1967;200(2):184. doi:10.1001/jama.1967.03120150140045