May 1, 1967

Parenteral Vitamin Therapy

JAMA. 1967;200(5):419. doi:10.1001/jama.1967.03120180107027

To the Editor:—  In her reply to Dr. Ginsburg's query (198:686, 1966), Dr. Grace Goldsmith stated that she saw "no reason for administering vitamins parenterally unless parenteral feeding were necessary." There are, however, other indications and, in the United Kingdom, Scandinavia, and certain European countries, high dosage parenteral vitamin therapy is widely used in the treatment of certain acute psychoses such as delirium tremens and acute confusional episodes. For that purpose there is at least one ethical pharmaceutical preparation on the market.1 The mode of action of such preparations is unknown since, except in the alcoholic, there is rarely any question of primary or secondary vitamin deficiency. Gould2,3 has postulated that the biochemical basis of certain acute psychoses secondary to the toxic effects of alcohol, for example, is one of interference with enzymatic activity in the cerebral utilization of glucose, and that saturation of the tissues with

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