The Book Forum
May 1, 1967

The Ultrastructure of the Normal Human Glomerulus

JAMA. 1967;200(5):422. doi:10.1001/jama.1967.03120180110037

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This monograph is another highly detailed description of the electron microscopic structure of the human renal glomerulus. The ultra-structure of the normal malpighian corpuscle is described and shown in 100 pages of text and 42 high-quality electron micrographs. The material studied consisted of 24 preoperative biopsies from patients free of renal disease. Previous light and electron microscopic studies of glomerular structure and development in man and in various animals are discussed, including a historical review. The main merit of this monograph, however, resides in the very careful investigation of the width of the glomerular basement membrane. On the basis of multiple planimetric determinations and detailed statistical analysis it is concluded that the basement membrane measures 3,300 to 3,400 Angstrom units. The variations from the mean were found to be approximately 20%, pointing to the difficulty inherent in any attempt to determine a standard measure for a biological spectrum. This careful

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