One of us (M.H.B.) had observed that the number of erythroblasts is increased in the marrow of patients with chronic myelocytic (granulocytic) leukemia who have bled chronically. This erythroblastic hyperplasia, in patients with a malignant proliferation of granulocytes, has considerable theoretical significance. In three cases of chronic myelocytic leukemia increased red blood cell production and erythroblastic hyperplasia resulted from chronic bleeding. In one case the bleeding was spontaneous; in the other two cases repeated phlebotomies were done to stimulate erythropoiesis.
Materials and Methods
One unit of whole blood (500 ml) was removed each week from two patients (cases 1 and 2) unless hemoglobin level was considerably lower than the previous week, or unless it was below 11.0 gm/100 ml. The iron lost at each phlebotomy was replaced intravenously with 5 ml of iron dextran injection (Imferon) containing 250 mg of elemental iron. We occasionally gave iron dextran injection even when
Goodman SB, Block MH. Increased Red Blood Cell Production in Chronic Myelocytic Leukemia. JAMA. 1967;200(7):621–624. doi:10.1001/jama.1967.03120200099022