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November 3, 1962

New Adhesive May Simplify Heart Surgery

JAMA. 1962;182(5):57. doi:10.1001/jama.1962.03050440109043

A flexible new adhesive that can be applied over incisions in blood vessels may simplify the surgeon's work in completing heart operations, according to surgeons from Children's Hospital Medical Center in Boston.

Experimental animal studies have shown that a group of synthetic resins, Polyurethane prepolymers, formed a "firm, stable, elastic, end-product" which "adequately sealed" blood vessel incisions. Dr. William F. Bernhard, principal investigator told the American Heart Association meeting.

The major advantage of the new adhesive, he said, is its ability to stretch with the vessel when blood pulses through it.

Agents previously developed, he pointed out, are generally "unsatisfactory" because they are brittle and produce severe tissue reaction after application.

By contrast, he added, inflammation of tissues surrounding the new flexible adhesive was mild.

Bernhard suggested four circumstances where the new adhesive may prove of future