November 10, 1962


JAMA. 1962;182(6):674-675. doi:10.1001/jama.1962.03050450074016

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Carcinoma cervix accounts for 75% of all the malignant tumors. Approximately 29,000 new cases of cervical cancers are diagnosed each year in the United States. About 10,000 women die each year of this disease. In the past 2 decades remarkable progress has been made in the fields of surgery, radiation therapy (see p. 637), and chemotherapeutic agents. These have significantly reduced the mortality rate from various types of cancer. The early detection of cancer in its incipient stages offers more expectation of a significant reduction in mortality than any change in the present mode of therapy. This is the primary purpose of exfoliative cytology. Exfoliation of epithelial cells of the female generative tract is occurring continuously. The degree of desquamation of proportional to the proliferative activity of the epithelium. Malignant cells proliferate more rapidly and as a result of this rapid growth they exfoliate to a greater degree than do

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