To the Editor:—
Ulcerative colitis is a systemic disease, frequently involving the skin, eyes, joints, and liver, without affecting other areas of the gastrointestinal tract. A most unusual example of ulcerative colitis associated with ulcerative esophagitis and chronic hepatitis was encountered recently.
Report of a Case:—
A generalized maculopapular eruption, lymphadenopathy, and splenomegaly developed in a 15-year-old white boy in December 1962; intermittent fever, malaise, and watery diarrhea followed. In January 1964, marked hepatomegaly and cervical and axillary lymphadenopathy were found. The total bilirubin was 5 mg/100 ml, alkaline phosphatase, 22 Bodansky units, and total serum protein, 10.5 gm/100 ml, with a diffusely increased γ-globulin on protein electrophoresis, ranging from 4.5 to 5.1 gm/100 ml (normal 0.6-1.5 gm/ 100 ml). Ultracentrifugation revealed that the γ-globulin was primarily 7S with a normal amount of macroglobulin. The serum glutamic oxaloacetic transaminase level ranged from 400 to 1,000 units. The latex agglutination test
Knudsen KB, Sparberg M. Ulcerative Esophagitis And Ulcerative Colitis. JAMA. 1967;201(2):140. doi:10.1001/jama.1967.03130020086028