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Article
July 17, 1967

CYANOACRYLATE TISSUE ADHESIVES

JAMA. 1967;201(3):195. doi:10.1001/jama.1967.03130030065017
Abstract

The n-alkyl alpha cyanoacrylate monomers have the ability to adhere to moist living tissues. Methyl cyanoacrylate monomer, in particular, has been used since 1960 by many investigators as a tissue adhesive for various surgical procedures. However, the monomer is not widely used in clinical surgery, because of two factors: histotoxicity and relative failure of adhesive vs suture techniques.

The success of surgical application of the cyanoacrylate monomer is dependent on the development of new surgical techniques suitable for use with monomers, in addition to development of a better monomer. Studies are presently being carried out to evaluate the various higher n-alkyl alpha cyanoacrylates used for the surgery of internal organs, as reported in a recent issue of the Archives of Surgery.1 Work with the higher homologs of the n-alkyl alpha cyanoacrylates has indicated that, as one proceeds up the homologous series, histotoxicity decreases.2 The higher homologs wet, spread,

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