Chronically impaired heat regulation may occur in diffuse scleroderma and may predispose to the development of heat stroke. Fatal heat stroke occurred in a patient with extensive sclerodermatous skin replacement. Patients with diffuse scleroderma should be advised to avoid high ambient temperatures.
Buchwald I, Davis PJ. Scleroderma With Fatal Heat Stroke. JAMA. 1967;201(4):270-271. doi:10.1001/jama.1967.03130040066023