August 14, 1967

Malignant Bladder Tumors in a Man and His Three Sons

Author Affiliations

From the Epidemiology Branch (Dr. Fraumeni) and Pathologic Anatomy Branch (Dr. Thomas). National Cancer Institute, National Institutes of Health. Bethesda, Md.

JAMA. 1967;201(7):507-509. doi:10.1001/jama.1967.03130070027006

Bladder carcinoma developed in a man and his three sons. Chemical exposures suspected in bladder carcinogenesis could not be identified in the environment of this family, so a genetically controlled mechanism was considered. Urinary tryptophan metabolites, which have been implicated in the origin of some forms of bladder cancer, were normal in the two survivors with this neoplasm.