Bladder carcinoma developed in a man and his three sons. Chemical exposures suspected in bladder carcinogenesis could not be identified in the environment of this family, so a genetically controlled mechanism was considered. Urinary tryptophan metabolites, which have been implicated in the origin of some forms of bladder cancer, were normal in the two survivors with this neoplasm.
Fraumeni JF, Thomas LB. Malignant Bladder Tumors in a Man and His Three Sons. JAMA. 1967;201(7):507-509. doi:10.1001/jama.1967.03130070027006