Therapeutic lithium doses for mania are approximately 50 mEq/day, and maintenance or prophylactic doses for recurrent manias and depressions are approximately 25 mEq/day. Patients must be examined carefully before lithium treatment and must be kept under clinical and laboratory control during treatment.
Schou M, Baastrup PC. Lithium Treatment of Manic-Depressive DisorderDosage and Control. JAMA. 1967;201(9):696-698. doi:10.1001/jama.1967.03130090060020