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August 28, 1967

Lithium Treatment of Manic-Depressive DisorderDosage and Control

Author Affiliations

From the Psychopharmacology Research Unit, Aarhus University Psychiatric Institute, Risskov, Denmark (Dr. Schou), and Glostrup Psychiatric Hospital, Glostrup, Denmark (Dr. Baastrup).

JAMA. 1967;201(9):696-698. doi:10.1001/jama.1967.03130090060020

Therapeutic lithium doses for mania are approximately 50 mEq/day, and maintenance or prophylactic doses for recurrent manias and depressions are approximately 25 mEq/day. Patients must be examined carefully before lithium treatment and must be kept under clinical and laboratory control during treatment.