In spite of earlier investigator's reports, detailed oscillometric evaluation of peripheral circulation has not produced proof of a significant vasodilating effect of procaine hydrochloride in a series of 55 patients. No blood pressure alteration or other adverse effects occurred. However, prior to the intra-arterial administration of procaine, clinically significant arteriospasm was observed in 38 of 885 arteriographic procedures. After the routine use of procaine, clinical arteriospasm was observed in only two of 1,197 arteriographic procedures, and no arterial or venous thromboses complicated arteriography.
Howland WJ, Curry JL, Wheeler PP. Intra-arterial Administration of Procaine Hydrochloride After ArteriographyPotential Value in Preventing Arteriospasm and Thrombosis. JAMA. 1967;201(11):813–816. doi:10.1001/jama.1967.03130110039009