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Sept 11, 1967

Estimation of Thyroid Function by Timing the Arterial Sounds

Author Affiliations

From Hahnemann Medical College and Hospital, Philadelphia (Dr. D. Rodbard), University of Tokyo (Dr. Fujita), and City of Hope Medical Center, Duarte, Calif (Dr. S. Rodbard). Dr. D. Rodbard is now at the National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md.

JAMA. 1967;201(11):884-887. doi:10.1001/jama.1967.03130110110038

The timing of the Korotkoff arterial sounds with reference to the electrocardiogram provides an objective index of thyroid function which is precise, accurate, rapid, innocuous, inexpensive, and independent of iodine metabolism. QKd is the interval between the QRS and the onset of Korotkoff sounds at diastolic pressure. The QKd value in 80 euthyroid subjects had a normal range of 186 to 235 msec. Ten patients with hypothyroidism had QKd values ranging from 230 to 320 msec.