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Article
Sept 18, 1967

MEDICAL NEWS

JAMA. 1967;201(12):19-30. doi:10.1001/jama.1967.03130120005003

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Abstract

Patients Aided By Cadaver Livers  Clinical experience with an extracorporeal hepatic support system utilizing a cadaver liver has been reported by a team of Milwaukee surgeons.The group is headed by Joseph C. Darin, MD, associate professor of surgery at Marquette University School of Medicine.In an interview with JAMAMedical News, James F. Romer, MD, surgical resident under Dr. Darin, described the clinical course of four patients in hepatic coma who were treated by perfusing their blood through cadaver livers.The first, a 41-year-old alcoholic cirrhotic, had been in coma for three days before being moved to Milwaukee County General Hospital. After just one hour of perfusion (total perfusion time was 4 1/2 hours), she became conscious and remained so, until dying a septic death fourteen days after the procedure. (The routine jejunostomy required for feeding had suddenly leaked, spilling bowel contents into the peritoneal cavity.)During the

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