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October 2, 1967

Immunity of School Children Two Years After Oral Poliomyelitis Vaccination

Author Affiliations

From the Department of Pediatrics, Western Reserve University School of Medicine, and Cleveland Metropolitan General Hospital, Cleveland.

JAMA. 1967;202(1):27-31. doi:10.1001/jama.1967.03130140085012

A serologic survey of the poliovirus immunity of children in a suburban school system was performed in 1964, two years after a mass oral vaccination program. Approximately 6% of the school children were studied and 96% had antibody titers of 8 or greater to all three types of poliovirus. Antibody levels declined during the two-year period, but only significantly so for types 2 and 3 in children who had not received a booster. Antibody titers to types 2 and 3 poliovirus in children who had been given a booster were significantly higher than those who had not received one. A single feeding of a trivalent live oral poliovirus vaccine resulted in a rise in antibody titer in slightly less than half of the subjects with low type 3 titers.