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November 6, 1967


JAMA. 1967;202(6):27-40. doi:10.1001/jama.1967.03130190011003

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Test Reduces Hepatitis Transmission  Early detection of elevated immunoglobulin levels in blood donors could pick out 50% to 60% of hepatitis carriers, Mayo Clinic and Graduate School of Medicine investigators believe.Preliminary studies involving 63 donors implicated in incidents of hepatitis transmission identified abnormally high immunoglobulin levels in 21 of them, according to Gerald Bevan, MB.Although immunoglobulin elevations are nonspecific criteria, inapparent diseases other than hepatitis —such as infectious mononucleosis —also would preclude use of a donor's blood.The Rochester, Minn, studies were spurred by observations at other centers that some hepatitis patients had heightened antibody titers months or years after clinical signs disappeared. Although prospective donors with a history of hepatitis would be excluded, elevated immunoglobulin levels might also exist in the carrier state.A simple immunodiffusion test on agar plates was used. Specific antisera for the various immunoglobulins were added to serum samples and the precipitates