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May 24, 1971

Amebic Abscess of Liver Following Metronidazole Therapy

Author Affiliations

From the United States Naval Hospital, Yokosuka, Japan.

JAMA. 1971;216(8):1339-1340. doi:10.1001/jama.1971.03180340059016

Five patients developed amebic abscess from one to three months after apparent successful treatment of amebic colitis with metronidazole. This observation suggests that metronidazole, although a highly effective amebicide, should not be used as the single agent in therapy of amebic colitis.