During a recent eight-month deployment of an aircraft carrier to the western Pacific, 230 cases of acute gonorrheal urethritis were encountered. Patients were randomly assigned to one of four treatment schedules: (1) procaine penicillin G for ten days; (2) procaine penicillin G in a large single dose; (3) penicillin G potassium for three days; and (4) oxytetracycline. Eradication of the gonococcus was highest with regimens 2 and 4. Cure of gonorrhea and prevention of nongonorrheal urethritis was highest with the oxytetracycline regimen.
Berry BE. Treatment of Gonorrheal Urethritis Evaluated in 230 Men. JAMA. 1967;202(7):657-659. doi:10.1001/jama.1967.03130200143032