Idiopathic thrombocytopenic purpura (ITP) in childhood is usually a benign, self-limited illness. Life-threatening complications, such as central nervous system (CNS) hemorrhage, occur in less than 1% of cases. We report a case in which the patient failed to respond to splenectomy and highdose corticosteroid therapy. Immunosupressive therapy with cyclophosphamide, vincristine sulfate, and corticosteroids in conjunction with frequent transfusions of platelets was associated with a complete remission that persisted after therapy was discontinued.
(JAMA 232:734-737, 1975)
Lightsey AL, McMillan R, Koenig HM. Childhood Idiopathic Thrombocytopenic PurpuraAggressive Management of Life-Threatening Complications. JAMA. 1975;232(7):734–736. doi:10.1001/jama.1975.03250070030019