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May 19, 1975

Childhood Idiopathic Thrombocytopenic PurpuraAggressive Management of Life-Threatening Complications

Author Affiliations

From the departments of pediatrics and hematology, and the Clinical Investigation Center, Naval Regional Medical Center, San Diego (LCDRs Lightsey and Koenig), and the L. C. Jacobson Blood Center, Scripps Clinic and Research Foundation, La Jolla, Calif (Dr. McMillan).

JAMA. 1975;232(7):734-736. doi:10.1001/jama.1975.03250070030019

Idiopathic thrombocytopenic purpura (ITP) in childhood is usually a benign, self-limited illness. Life-threatening complications, such as central nervous system (CNS) hemorrhage, occur in less than 1% of cases. We report a case in which the patient failed to respond to splenectomy and highdose corticosteroid therapy. Immunosupressive therapy with cyclophosphamide, vincristine sulfate, and corticosteroids in conjunction with frequent transfusions of platelets was associated with a complete remission that persisted after therapy was discontinued.

(JAMA 232:734-737, 1975)