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June 2, 1975

Methanol Poisoning-Reply

JAMA. 1975;232(9):907. doi:10.1001/jama.1975.03250090010005

In Reply.—  Dr. Wenger's observations on an outbreak of diarrhea in infants that was thought, but not proved, to be complicated by methanol poisoning, are of interest from the dual standpoints of the effects of peritoneal dialysis on severe diarrhea of infancy as well as of its role in methanol poisoning. Metabolic acidosis, coma, and acute renal failure are not uncommon sequelae of severe diarrhea of infancy. In such cases, peritoneal dialysis easily corrects the acidosis. If the infant is very dehydrated, the osmotic gradient between serum and dialysate will favor a shift of water from the dialysate to the systemic circulation. In addition, the glucose in the dialysate is a source of nutrition for the infant. Lastly, the efficiency of peritoneal dialysis is greater in infants than in adults because of the greater ratio of peritoneal surface area to body surface in infants.With respect to methanol poisoning in