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December 11, 1967

Familial Osteosarcoma Fifth Reported Occurrence

Author Affiliations


JAMA. 1967;202(11):1055. doi:10.1001/jama.1967.03130240097023

To the Editor:—  In the course of preparing a review on familial tumors,1 many reports of unusual familial occurrence of tumors were found, including myelomas, chondrosarcomas, fibromas, lipomas, and other tumors of bone and soft tissues.' -6 Four previous instances of familial occurrence of osteosarcoma were found.7-10 It is the purpose of this paper to present what is believed to be the fifth such report.

Case 1:—  This 22-year-old man was first seen in May 1963 with a lump on the back of his head (Fig 1). In July a craniotomy and partial resection of a mass was done. It was 8×8 cm in dimensions and very vascular. It involved the flat bones of the posterior portion of the skull, the dura mater, and the sagittal sinus. Histologic examination revealed osteosarcoma. Brain scan revealed a large space-taking component intracerebrally. Radiation therapy to 6,000 rads in six weeks was administered.