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July 14, 1975

Principles of Pathobiology

Author Affiliations

University of Texas Medical Branch Galveston

JAMA. 1975;233(2):187. doi:10.1001/jama.1975.03260020073037

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This textbook is an excellent summation of the molecular, enzymatic, and ultramicroscopic changes in disease processes that demonstrate significant abnormalities at these levels. Included are chapters on cell injury, inflammation, host-parasite relationships, immunology, neoplasia, and developmental diseases. Although this is the second edition, only the chapter on cell injury appears to have been revised sufficiently to include a significant number of new references. For example, the chapter on developmental disease makes no mention of the potential of amniocentesis for prenatal diagnosis of genetic diseases.

The preface states that "The book is designed for easy use by busy students." It is not, however, suitable as the major source of information for a basic pathology course. Not included are disease processes that have no significant ultrastructural changes, such as hemodynamic disturbances. Even in the extensive chapter on cell injury there is not sufficient orientation to provide the medical student with a basis