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August 18, 1975

Corticosteroid Therapy for the Pregnant Asthmatic Patient

Author Affiliations

From the Section of Allergy-Immunology, Department of Medicine, Northwestern University Medical School, Chicago (Drs. Schatz, Patterson, O'Rourke, and Melam), and the Division of Allergy, Department of Medicine, University of Washington Medical School, Seattle (Dr. Zeitz). Dr. O'Rourke is now with the Department of Medicine, Geisinger Medical Center, Danville, Pa.

JAMA. 1975;233(7):804-807. doi:10.1001/jama.1975.03260070062025

Corticosteroids were used during seventy pregnancies in 55 asthmatic patients. In this series there was one spontaneous abortion and 71 live births (including two sets of twins). There were no maternal, fetal, or neonatal deaths. On the basis of recorded gestation, slightly more premature births were noted in this series than would be expected in the general population. However, there was no increased incidence of toxemia, uterine hemorrhage, or congenital malformations when compared to the general population, Corticosteroids, when indicated for the treatment of severe asthma, do not appear to noticeably increase the risk of maternal or fetal complications, and thus should not be contraindicated in pregnancy.

(JAMA 233:804-807, 1975)