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March 4, 1968

Autoimmunity in Concurrent Myasthenia Gravis and Pemphigus Erythematosus

Author Affiliations

From the Department of Bacteriology and Immunology, State University of New York at Buffalo, School of Medicine (Dr. Beutner and Mr. Hale); departments of dermatology (Dr. Chorzelski) and neurology (Dr. Hausmanowa-Petrusewicz), Warsaw Medical School.

JAMA. 1968;203(10):845-849. doi:10.1001/jama.1968.03140100027006

A patient with myasthenia gravis, a malignant thymoma, and pemphigus erythematosus was found to have antibodies to the cross striations of skeletal muscle, to the intercellular areas of stratified squamous epithelium, and to nuclei as revealed by indirect immunofluorescence. Somewhat comparable observations have been made in other cases. The concurrence of these rare immunologic derangements point to some common underlying mechanisms.