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August 2, 1971

Vitamin B2 and Vitamin E In Long-Term Hemodialysis

Author Affiliations

Gifu, Japan

JAMA. 1971;217(5):699. doi:10.1001/jama.1971.03190050155027

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To the Editor. —  Various metabolites of proteins, vitamins, and drugs are excreted by the kidney or intestines. Vitamin B2 and its metabolites are usually excreted by the former and vitamin E by the latter route.Patients receiving maintenance hemodialysis are usually anuric or oliguric, and vitamin B2 is automatically removed by the hemodialysis. Our previous investigation showed that the dialysis rate of total vitamin B2 in vivo using the Kiil dialyzer was 22.1 ± 9.2 ml/min (mean ± SD, n = 6), about one quarter of that of urea or creatinine. Serum creatinine and blood urea nitrogen levels are the main guidelines for patients receiving hemodialysis.We supposed that the plasma vitamin B2 content of patients receiving maintenance dialysis would be higher than in normal subjects, but not the vitamin E content. The plasma vitamin B2 and vitamin E content in these patients were determined