Euphoria, confusion, petit and grand mal convulsions, and respiratory arrest associated with infusion of lidocaine hydrochloride occurred in a patient with myocardial infarction. The neurological complications caused catastrophic deterioration of the patient's condition. The increasing use of lidocaine intravenously to treat ventricular arrhythmias makes it advisable that physicians become acquainted with the early neurological symptoms and signs of lidocaine toxicity.
Crampton RS, Oriscello RG. Petit and Grand Mal Convulsions During Lidocaine Hydrochloride Treatment of Ventricular Tachycardia. JAMA. 1968;204(3):201-204. doi:10.1001/jama.1968.03140160011003