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August 30, 1971

Absence of Interference of Oxazepam With Glucose Determination

Author Affiliations

Birmingham, Ala

JAMA. 1971;217(9):1244. doi:10.1001/jama.1971.03190090066018

To the Editor.—  Zileli and co-workers (215:1986, 1971) recently reported a case in which high blood glucose concentrations were found in a patient who had ingested "large doses" of oxazepam. These authors "dissolved one tablet (10 mg) of oxazepam in 2 ml of distilled water" and found that the "clear fluid obtained after centrifugation yielded 590 mg of glucose per 100 ml by Somogyi method, and 750 mg/100 ml of glucose by glucose oxidase reaction." They postulated that "it is possible that the hydroxy or ketone group or both in the oxazepam molecule is responsible for the glucose reaction." In addition, these authors state that "blood glucose levels (glucose-like reaction) may be found elevated in patients receiving therapeutic doses of oxazepam."It is my opinion that Zileli and co-workers are in error in their interpretation of their experiments in which oxazepam was pointed out as the compound reacting in