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September 20, 1971

Thioridazine in Schizophrenia

Author Affiliations

Norristown, Pa

JAMA. 1971;217(12):1705. doi:10.1001/jama.1971.03190120071024

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To the Editor.—  At Norristown (Pa) State Hospital, we have had considerable experience in the use of thioridazine (Mellaril), primarily with schizophrenics, but also with patients with nonpsychotic severe anxiety reactions. It is well known that thioridazine, because of its adrenolytic activity, inhibits or prevents ejaculation in some patients. Though not specifically dose-related, this phenomenon is generally more severe at higher dosages.Thioridazine has been shown to cause impotency in males and delay of orgasm in both men and women. Occasionally, thioridazine has been found to be effective in the treatment of premature ejaculation, prolonging the time between insertion and ejaculation. The exact basis of this effect is unknown but may be related to decrease in anxiety or a specific chemical effect on the sexual functioning.Schizophrenics, generally, are most disturbed by any changes in bodily function, whatever the cause, but especially in their sexual functioning. With the use of